| Part I | |||||||||||||||||
| 1. | Date of notice to issuer | 27/05/2008 | |||||||||||||||
| 2. | Name of Substantial Shareholder | UBS AG | |||||||||||||||
| 3. | Notice Type | Notice of a Change in the Percentage Level of a Substantial Shareholder's Interest or Cessation of Interest. | |||||||||||||||
| Part II - Not Required | |||||||||||||||||
| Part III | |||||||||||||||||
| 1. | Date of change of Interest | 26/05/2008 | |||||||||||||||
| 2. | The change in the percentage level | From 4.66 % To 4.33 % | |||||||||||||||
| 3. | Circumstance(s) giving rise to the interest or change in interest |
# Others THE CHANGE IS A RESULT OF THE FOLLOWING: (1) DECREASE IN SHARES IN BIO-TREAT TECHNOLOGY LIMITED RECEIVED AS COLLATERAL WHICH CARRY VOTING RIGHTS; (2) DECREASE IN DISCRETIONARY POSITIONS HELD ON BEHALF OF UBS GLOBAL ASSET MANAGEMENT CLIENTS; PARTIALLY OFFSET BY (3) INCREASE IN BORROWED SHARES IN BIO-TREAT TECHNOLOGY LIMITED WHICH CARRY VOTING RIGHTS |
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| 4. | A statement of whether the change in the percentage level is the result of a transaction or a series of transactions: | A SERIES OF TRANSACTIONS | |||||||||||||||
| Part IV | |||||||||||||||||
| 1. | Holdings of Substantial Shareholder, including direct and deemed interest : | ||||||||||||||||
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